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Prof. Bachelet, whose laboratory is at the �鶹��Ƶ Institute of Nanotechnology and Advanced Materials (BINA), has created a method of producing DNA molecules with characteristics that can be programmed to reach specific locations in the body, as well as carry out pre-programmed operations that can respond to stimulation from the body.

Overcoming a Problem in Drug Design

By agreeing to support this technology, Pfizer has expressed confidence in Prof. Bachelet’s approach that shows great promise in helping overcome a major problem in drug design — the fact that doctors have almost no control where or when a drug will be active once it is administered.

Prof. Bachelet’s system opens up new possibilities for bio-embedded computers that can work as a coordinated team, responding to cellular signals, making a drug available or unavailable at will, and controlling drug interactions.

Potential to Target Cancer Cells

In explaining how to make a nanometric robot, Bachelet says, “We first of all create a selected DNA sequence, and then fold it by using a process called DNA origami. With this method, a person can give a command to a computer, which folds the DNA molecule as needed.”

According to Bachelet, this method has the potential to target cancer cells. These types of cells can be targeted as a result of using the DNA sequence to make a form of a clam that contains an anti-cancer drug. He adds, “…the clam can be designed to change its shape and release the drug only when it meets a cancer cell or the right tissue.”

A Returning Scientist, Prof. Bachelet came to �鶹��Ƶ from the Massachusetts Institute of Technology (MIT) several years ago. He is among the 50 Returning Scientists who were brought back to Israel by �鶹��Ƶ, thanks in part to funding provided by supporters of the �鶹��Ƶ.